GE Healthcare Life Sciences is now Cytiva

Troubleshooting cell culture media for bioprocessing

Troubleshooting cell culture media for bioprocessing
Peggy Lio Director of Process Science, GE Healthcare


Cell culture media, including basal media and feeds, are key elements impacting the performance of bioprocesses. Advances in cellular and metabolic understanding, coupled with high-throughput applications, have evolved approaches in media development and optimization, resulting in innovative cell culture media with desired characteristics to meet specific needs.

However, challenges associated with the use of cell culture media still exist. Examples include manufacturability, suboptimal stability, inconsistent performance, and/or underperformance in terms of productivity and quality attributes. In some cases, troubleshooting efforts can be guided by learned know-how, but in other circumstances, a systematic approach is necessary to identify the root cause. 

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Peggy Lio
Director of Process Science

Peggy is currently Director of Process Science at GE Healthcare where she is responsible for leading the technical applications strategy for the US cell culture business. She joined GE from Life Technologies where she was responsible for the development of PD-Direct Bioprocess custom cell line and cell culture media optimization service programs globally. She also led an applications team charged with scientific support of new cell line and media products as well as process development. Prior to Life Technologies, Peggy held roles of increasing responsibility with Schering-Plough Corp., where she ultimately became Section Leader with responsibility for mammalian and microbial fermentation process development for a variety of biotechnology-based therapeutics. Peggy has over 30 years of extensive technical and commercial experience in bioprocessing along with multiple honors and awards from Schering and Life Technologies.


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